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E3 Ligase Ligand-linker Conjugate 147

E3 Ligase Ligand-linker Conjugate 147 is a conjugate of E3 ligase ligand and PROTAC Linker, which can be used to synthesize BRD9 Degrader-1 (HY-156401) (Compound 13-7) [1]. E3 Ligase Ligand-linker Conjugate 147 is composed of the E3 ligase ligand BRD9 ligand-7 (HY-168695) and the PROTA linker 2- ((1R,5S,6s) -3-Azabicyclo[3.1.0]hexan-6-yl) ethan-1-ol (HY-W763939) .

Product Specifications

UNSPSC

12352211

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-147.html

Smiles

[H][C@]12CNC[C@@]1([H])[C@@H]2CCOC3=CC(C4=C(C)N=CS4)=CC=C3CNC([C@H]5N(C([C@H](C(C)(C)C)NC(C6(CC6)F)=O)=O)C[C@@H](C5)O)=O

Molecular Formula

C33H44FN5O5S

Molecular Weight

641.80

References & Citations

[1]Liu S, et al. Rational Screening for Cooperativity in Small-Molecule Inducers of Protein-Protein Associations. J Am Chem Soc. 2023 Oct 25;145 (42) :23281-23291.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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