[Ala92]-p16 (84-103)

Product Specifications

CAS Number

189064-08-2

Target

CDK

Related Pathways

Cell Cycle/Checkpoint

Bioactivity

Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4) /cyclin D1 (IC50 ~ 1.5 ?M) and binds to cdk6.

Smiles

[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C)=O)=O)C)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)C)=O)C)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)=O)=O)CC(C)C)=O)C)=O)[C@@H](C)O)=O)CC(C)C)=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O