Rac1 Inhibitor W56

Rac1 Inhibitor W56 is a peptide consisting of residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. It selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1, and Tiam1.

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)C(C)C)=O)CC(O)=O)=O)=O)CCCCN)=O)CCC1)C(C)C)=O)CC(N)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)C=2C=3C(NC2)=CC=CC3