Urantide

Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3) . Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors) .

C(C=1C=2C(NC1)=CC=CC2)[C@H]3NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H](NC([C@H](CC(O)=O)N)=O)C(C)(C)SSC[C@@H](C(N[C@@H](C(C)C)C(O)=O)=O)NC(=O)[C@H](CC5=CC=C(O)C=C5)NC(=O)[C@H](CCCN)NC3=O