AC 253
Product Specifications
CAS Number
151804-79-4
Target
Beta Amyloid
Related Pathways
Neuroscience
Bioactivity
Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric A?-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of A? in vitro. Cyclic AC 253 also available.
Smiles
C([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC(C)C)NC(C)=O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(N)=O)=O)[C@@H](C)O)=O)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)CO)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC3
Molecular Formula
C122H196N40O39
Molecular Weight
2847.11
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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