Cyclotraxin B

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM) . Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

O=C1N2[C@](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC3=CC=C(O)C=C3)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@H](C(O)=O)CSSC[C@H](N)C(=O)N[C@H]1CC(N)=O)[H])(CCC2)[H]