α-Conotoxin PIA

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively) .

O=C1N2[C@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@H](C(N)=O)CSSC[C@@]3(NC(=O)[C@@H](NC(=O)[C@H]4N(C([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CC(O)=O)=O)CCC4)CSSC[C@@](C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC5=CN=CN5)C(=O)N[C@H]1CC(N)=O)[H])(NC(=O)[C@H](C(C)C)NC(=O)[C@]6(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC3=O)CCC6)[H])[H])[H])[H])(CCC2)[H]