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Calcineurin Autoinhibitory Peptide

Product Specifications

CAS Number

148067-21-4

Target

Phosphatase

Related Pathways

Metabolism

Bioactivity

Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM) . Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM) .

Smiles

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)[C@@H](C)O)=O)CO)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)=O)CC(C)C)=O)CC(O)=O)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CC(N)=O)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)CCSC)=O)CCC1)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(O)=O)CCC4)CCSC)=O)C)=O)CC(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC3

Molecular Formula

C124H205N39O39S2

Molecular Weight

2930.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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