[D-Ala2]-GIP (human)
Product Specifications
CAS Number
444073-04-5
Target
IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM) . Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD.
Molecular Formula
C226H338N60O66S
Molecular Weight
4983.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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