HS014
Product Specifications
CAS Number
207678-81-7
Target
Melanocortin Receptor
Related Pathways
Neuroscience|||GPCR/G Protein
Bioactivity
Potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively) . Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1?-induced Fos expression in the paraventricular hypothalamus.
Smiles
C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N7[C@H](C(=O)N8[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N)=O)=O)CCCCN)=O)CCC8)CCC7)NC(=O)CNC3=O
Molecular Formula
C71H94N20O17S2
Molecular Weight
1563.77
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/291A9AD2-B08D-46C0-A077-22AA1D05CF08/TP2015
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