Lyn peptide inhibitor

Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC(CNC([C@H](CC2=CC=C(O)C=C2)NC(CCCCCCCCCCCCCCCCC)=O)=O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(=O)N4[C@H](C(N)=O)CCC4)CC(N)=O)=O)CCC3)[C@H](CC)C)=O)CCCCN)=O)CCC(O)=O)=O)CCC(O)=O)=O)C=5C=6C(NC5)=CC=CC6