MM 54

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM) . Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

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