Norleual
Product Specifications
CAS Number
334994-34-2
Target
RAAS|||c-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Endocrinology/Hormones
Bioactivity
Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM) . Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
Smiles
C([C@H](CC1=CN=CN1)NC[C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCCC)N)=O)=O)CC(C)C)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)CCC3
Molecular Formula
C41H58N8O7
Molecular Weight
774.95
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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