[Arg14, Lys15]Nociceptin

Highly potent and selective NOP receptor agonist (EC50 = 1 nM) . Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively) . Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

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