187-1, N-WASP inhibitor

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2) -stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.

O=C1N2C(C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N5[C@@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC6=CC=CC=C6)C(=O)N7C(C(=O)N[C@H](CC8=CC=CC=C8)C(=O)N[C@@H](CC9=CC=CC=C9)C(=O)N%10[C@@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1CC%11=CC=CC=C%11)(CCC%10)[H])(CCC7)[H])(CCC5)[H])(CCC2)[H]