Obtustatin
Product Specifications
Target
Integrin
Related Pathways
Cytoskeletal Signaling
Bioactivity
Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen) . Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
Molecular Formula
C184H284N52O57S8
Molecular Weight
4393.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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