QWF
Product Specifications
CAS Number
126088-82-2
Target
Neurokinin receptor
Related Pathways
GPCR/G Protein, Neuroscience
Bioactivity
Tripeptide substance P (SP) antagonist (IC50 = 90 μM) . Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
Smiles
C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(OCC2=CC=CC=C2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CCC(N)=O)=O)C=3C=4C(N(C=O)C3)=CC=CC4
Molecular Formula
C38H43N5O8
Molecular Weight
697.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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