Ac-RYYRWK-NH2

Potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM) . Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM) . Increases food intake in vivo.

C([C@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCCNC(=N)N)NC(C)=O)=O)=O)=O)CCCNC(=N)N)=O)C(N[C@@H](CCCCN)C(N)=O)=O)C=3C=4C(NC3)=CC=CC4