R715 TFA (185052-09-9 free base)
Product Specifications
Target
Bradykinin Receptor
Related Pathways
GPCR/G Protein
Purity
>99.99%
Bioactivity
R715 TFA (185052-09-9 free base) is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49) . Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
Smiles
CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)[C@@H]4CCCN4C(=O)[C@@H]5CCCN5C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)C.OC(C(F)(F)F)=O
Molecular Formula
C59H82F3N13O14
Molecular Weight
1254.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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