[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) ; diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

C([C@H](C(N[C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)NC([C@@H](NC([C@H](NC(=O)[C@H]4N(C([C@@H](NC(=O)[C@H]5N(C([C@@H](CCCNC(=N)N)N)=O)CCC5)CCCCN)=O)CCC4)CC6=CC=CC=C6)=O)CCC(N)=O)=O)C=7C=8C(NC7)=CC=CC8