D[Leu4, Lys8]-VP

Selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively) . Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.

C(=O)(N1[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCCN)=O)CCC1)[C@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)CCSSC2