FSLLRY-NH2 TFA (245329-02-6 free base)
Product Specifications
Target
Protease-activated Receptor
Related Pathways
GPCR/G Protein
Purity
0.9932
Bioactivity
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
Smiles
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)N.O=C(O)C(F)(F)F
Molecular Formula
C41H61F3N10O10
Molecular Weight
910.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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