KYL acetate (676657-00-4 free base)

KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM) ; inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM) . Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively) . Neuroprotective.

O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@H]3N(CCC3)C([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56.CC(O)=O