KYL peptide

KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 ?M) ; inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 ?M) . Prevents A?O induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively) . Neuroprotective.

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