K- (D-1-Nal) -FwLL-NH2

High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively) . Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](CC=2C3=C(C=CC2)C=CC=C3)NC([C@H](CCCCN)N)=O)=O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)C=4C=5C(NC4)=CC=CC5