NoxA1ds acetate (1435893-78-9 free base)
Product Specifications
Target
NADPH-oxidase
Related Pathways
Immunology/Inflammation
Purity
0.9692
Bioactivity
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM) . Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
Smiles
C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)N.CC(=O)O
Molecular Formula
C52H92N14O17
Molecular Weight
1185.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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