What is the catalog number for Maurocalcine?

The catalog number for Maurocalcine is HY-P5114.

What sizes are available for Maurocalcine?

Maurocalcine is available in the following size(s): 1 Each.

Is Maurocalcine in stock?

Maurocalcine is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Maurocalcine?

Maurocalcine is manufactured by QuantiMol.

What is the estimated delivery time for Maurocalcine?

Estimated delivery time for Maurocalcine is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Maurocalcine?

The safety data sheet for Maurocalcine is available here: http://file.medchemexpress.com/batch_PDF/HY-P5114/.

Maurocalcine

Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].

Product Specifications

CAS Number

269745-22-4

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/maurocalcine.html

Solubility

10 mM in DMSO

Smiles

O=C(CN)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CCCCN)=O)CC(N)=O)=O)CCC(O)=O)=O)CCCCN)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CCCNC(N)=N)=O)CCCCN)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC(N)=O)=O)[C@@H](C)O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CC5=CNC=N5)=O)CCC1)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H]4CCCCN)=O)CCCCN)=O)CO)=O)=O)CC(O)=O

Molecular Formula

C156H270N56O46S6

Molecular Weight

3858.55

References & Citations

[1]De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477 (20) :3985-3999.|[2]Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406 (2) :309-15.|[3]Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758 (3) :308-19.