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PUMA BH3

Product Specifications

Target

Bcl-2 Family

Related Pathways

Apoptosis

Bioactivity

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide that acts as a direct activator of Bak with a Kd of 26 nM. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53, potentially mediating p53-induced apoptosis.

Molecular Formula

C128H202N42O43S

Molecular Weight

3049.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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