PUMA BH3
Product Specifications
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide that acts as a direct activator of Bak with a Kd of 26 nM. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53, potentially mediating p53-induced apoptosis.
Molecular Formula
C128H202N42O43S
Molecular Weight
3049.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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