G280-9

The G280-9 peptide, a common melanoma gp100 epitope restricted by MHC-associated HLA-A2. The G280-9 sequence is unique because it could be recognized by cytotoxic T lymphocytes at very low concentrations, however it shows low total immunogenicity that may be attributable to relatively low affinity of this peptide for the HLA-A2.

C([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)CC(C)C)=O)CCC(O)=O)(=O)N2[C@H](C(NCC(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)[C@@H](C)O)=O)[C@@H](C)C)=O)CCC3)=O)CCC2