Jagged-1 (188-204)

Product Specifications

CAS Number

219127-21-6

Target

Gamma-secretase

Related Pathways

Stem Cells|||Proteases/Proteasome|||Neuroscience

Bioactivity

Jagged-1 (188-204) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-?B activation.

Smiles

O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](Cc6ccc(O)cc6)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS