HIF-1 alpha (556-574)

HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as a master regulator of oxygen homeostasis by initiating hypoxia-induced gene expression when the HIF-1 subunit is stabilized due to lack of oxygen. This fragment binds to the von Hippel-Lindau factor (VHL), an E3 ubiquitin ligase, with proline 564 being essential to the binding process.

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