CTTHWGFTLC, CYCLIC

This cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP) -2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.

C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@@H](N)CSSC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)CNC3=O)[H])[H])[H]