Peptide 401

Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhibits some anti-inflammatory activity, decreasing paw edema in animal models.

O=C1[C@]2(N(C(=O)[C@H](CCCCN)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H]([C@H](C)C)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@]4(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CCCCN)=O)CSSC[C@](NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CC5=CN=CN5)N1)[H])(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CCCCN)=O)=O)CSSC4)[H])[H])[H])[H])CCC2)[H]