Isorhapontigenin
Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation[1][2].
Product Specifications
CAS Number
32507-66-7
UNSPSC
12352005
Hazard Statement
H315, H318, H335
Target
Autophagy
Type
Natural Products
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isorhapontigenin.html
Purity
99.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC(O)=CC(/C=C/C2=CC(OC)=C(O)C=C2)=C1
Molecular Formula
C15H14O4
Molecular Weight
258.27
Precautions
H315, H318, H335
References & Citations
[3]Jiang G, et al. Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis. Cancer Prev Res (Phila) . 2016 Jul;9 (7) :567-80.|[1]Yeo SCM, et al. Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Br J Pharmacol. 2017 Jul;174 (13) :2043-2059.|[2]Liang Y, et al. SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers. Autophagy. 2016 Aug 2;12 (8) :1229-39.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
