Isorhapontigenin

Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation[1][2].

Product Specifications

CAS Number

[32507-66-7]

UNSPSC

12352005

Hazard Statement

H315, H318, H335

Target

Autophagy

Type

Natural Products

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isorhapontigenin.html

Purity

99.82

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC(O)=CC(/C=C/C2=CC(OC)=C(O)C=C2)=C1

Molecular Formula

C15H14O4

Molecular Weight

258.27

Precautions

H315, H318, H335

References & Citations

[3]Jiang G, et al. Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis. Cancer Prev Res (Phila) . 2016 Jul;9 (7) :567-80.|[1]Yeo SCM, et al. Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Br J Pharmacol. 2017 Jul;174 (13) :2043-2059.|[2]Liang Y, et al. SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers. Autophagy. 2016 Aug 2;12 (8) :1229-39.