Isorhapontigenin
Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation[1][2].
Product Specifications
CAS Number
32507-66-7
UNSPSC
12352005
Hazard Statement
H315, H318, H335
Target
Autophagy
Type
Natural Products
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isorhapontigenin.html
Purity
99.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC(O)=CC(/C=C/C2=CC(OC)=C(O)C=C2)=C1
Molecular Formula
C15H14O4
Molecular Weight
258.27
Precautions
H315, H318, H335
References & Citations
[3]Jiang G, et al. Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis. Cancer Prev Res (Phila) . 2016 Jul;9 (7) :567-80.|[1]Yeo SCM, et al. Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Br J Pharmacol. 2017 Jul;174 (13) :2043-2059.|[2]Liang Y, et al. SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers. Autophagy. 2016 Aug 2;12 (8) :1229-39.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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