Iprodione

Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS) . Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats[1][2][3][4][5].

Product Specifications

CAS Number

[36734-19-7]

UNSPSC

12352005

Hazard Statement

H351

Target

Androgen Receptor; Fungal; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/iprodione.html

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C(N1C2=CC(Cl)=CC(Cl)=C2)=O)CC1=O)NC(C)C

Molecular Formula

C13H13Cl2N3O3

Molecular Weight

330.17

Precautions

H351

References & Citations

[1]Reilly C C, et al. The Effects of the Fungicide, Iprodione, on the Mycelium of Sclerotinia sclerotiorum[J]. Phytopathology, 1981, 71 (7) : 722-727.|[2]Griffiths RG, et al. Lipid composition of Botrytis cinerea and inhibition of its radiolabelling by the fungicide iprodione. New Phytol. 2003 Oct;160 (1) :199-207. |[3]Radice S, et al. Effect of iprodione, a dicarboximide fungicide, on primary cultured rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol. 2001 Sep;54 (1-2) :51-8. |[4]Abd-Elhakim Y M, et al. Iprodione and Chlorpyrifos, Alone and in a Mixture, Impaired Male Fertility and Sexual Behavior in Adult Rats via Suppression of Steroidogenic Genes and SIRT1/TERT/PGC-1α Pathway[J]. 2021.|[5]Blystone CR, et al. Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production. Toxicol Lett. 2007 Nov 1;174 (1-3) :74-81.