2'-β-C-Ethynyladenosine
Product Specifications
CAS Number
640725-76-4
Target
Nucleoside Antimetabolite/Analog|||HCV Protease
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Proteases/Proteasome|||Microbiology/Virology
Bioactivity
2'-?-C-Ethynyladenosine is a synthetic nucleoside analog that functions as a potent inhibitor of hepatitis C virus (HCV) replication by targeting the viral RNA-dependent RNA polymerase, NS5B; it inhibits HCV subgenomic replicon replication and NS5B-catalyzed RNA synthesis with half-maximal inhibitory concentration (IC50) values of 0.3 micromolar and 1.9 micromolar, respectively, and also demonstrates potent inhibitory activity against Leishmania RNA Virus 1 (LRV1) in species such as Leishmania guyanensis (Lgy) and Leishmania braziliensis.
Smiles
C(#C)[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3
Molecular Formula
C12H13N5O4
Molecular Weight
291.26
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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