4- (6-Bromo-2-benzothiazolyl) benzenamine

4- (6-Bromo-2-benzothiazolyl) benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.

Product Specifications

CAS Number

[566169-97-9]

UNSPSC

12352005

Target

Amyloid-β; Oxidative Phosphorylation

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-_6-Bromo-2-benzothiazolyl_benzenamine.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

NC1=CC=C(C2=NC3=CC=C(Br)C=C3S2)C=C1

Molecular Formula

C13H9BrN2S

Molecular Weight

305.19

References & Citations

[1]Klunk W, et al. Benzothiazole derivative compounds, compositions and uses. WO2004083195 A1|[2]Chen YK, et al. Apoptosis induced by 2-aryl benzothiazoles-mediated photodynamic therapy in melanomas via mitochondrial dysfunction. Chem Res Toxicol. 2014 Jul 21;27 (7) :1187-98.