Tyrphostin AG213

Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM) . Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM) . Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].

Product Specifications

CAS Number

[122520-86-9]

Product Name Alternative

AG213

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR; Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tyrphostin-ag213.html

Solubility

10 mM in DMSO

Smiles

S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1

Molecular Formula

C10H8N2O2S

Molecular Weight

220.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Romer LH, et al. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell. 1994 Mar;5 (3) :349-61.