Tyrphostin AG213
Product Specifications
UNSPSC Description
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].
Target Antigen
EGFR; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyrphostin-ag213.html
Solubility
10 mM in DMSO
Smiles
S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1
Molecular Weight
220.25
References & Citations
[1]Romer LH, et al. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell. 1994 Mar;5(3):349-61.
Shipping Conditions
Room temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101959/Tyrphostin-AG213-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101959/
Clinical Information
No Development Reported
CAS Number
122520-86-9
Available Sizes
Curated Selection
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