Tyrphostin AG213
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM) . Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM) . Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].
Product Specifications
CAS Number
[122520-86-9]
Product Name Alternative
AG213
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyrphostin-ag213.html
Solubility
10 mM in DMSO
Smiles
S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1
Molecular Formula
C10H8N2O2S
Molecular Weight
220.25
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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