Notoginsenoside R4

Cytoskeletal Signaling, Apoptosis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Proteases/Proteasome, Stem Cells, Angiogenesis, PI3K/Akt/mTOR signaling

Notoginsenoside R4 is a ginsenoside obtainable from ginseng roots and participates in molecular docking interactions with core disease-related targets including STAT3, AKT1, HRAS, VEGFA, and CASP3, demonstrating favorable binding affinity. These docking results of Notoginsenoside R4, complemented by visualization analyses, highlight Notoginsenoside R4 as an important functional constituent of Panax notoginseng saponins (PNS) with mechanistic implications for anticancer and pro-apoptotic signaling regulation.

C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4)CC3)[H])(C[C@@H](O)[C@]6([C@@]2(C)CC[C@@]6([C@@](O[C@@H]7O[C@H](CO[C@@H]8O[C@H](CO[C@H]9[C@H](O)[C@@H](O)[C@H](O)CO9)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@H]7O)(CCC=C(C)C)C)[H])[H])[H]