Selaginellin
Product Specifications
CAS Number
941269-84-7
Target
Sirtuin, Reactive Oxygen Species
Related Pathways
NF-κB, Immunology/Inflammation, Chromatin/Epigenetic, Metabolism, DNA Damage/DNA Repair
Bioactivity
Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows inhibitory effect on high glucose-induced cell injury and apoptosis in differentiated PC12 cells, which is related to inhibition of LOX-1/NADPH oxidase-reactive oxygen species/caspase-3 signaling pathway.
Smiles
O=C1C=CC(C=C1)=C(C2=CC=C(O)C=C2)C3=C(C#CC4=CC=C(O)C=C4)C(=CC=C3C=5C=CC(O)=CC5)CO
Molecular Formula
C34H24O5
Molecular Weight
512.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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