Trypsin

Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation[1][2][3][4][6].

Product Specifications

CAS Number

[9002-07-7]

UNSPSC

12352211

Hazard Statement

H315, H319, H334, H335

Target

Protease Activated Receptor (PAR) ; Ser/Thr Protease

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trypsin.html

Purity

91.00

Solubility

H2O : ≥ 10 mg/mL

Smiles

[Trypsin]

Precautions

H315, H319, H334, H335

References & Citations

[1]Bhupendra S.Kaphalia. Chapter 16 - Biomarkers of acute and chronic pancreatitis. Biomarkers in Toxicology. 2014, Pages 279-289. |[2]Yue-Lin Yang, et al. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerg Microbes Infect. 2020 Feb 24;9 (1) :457-468. |[3]H Amano, et al. Trypsin promotes C6 glioma cell proliferation in serum- and growth factor-free medium. Neurosci Res. 1996 Jul;25 (3) :203-8. |[4]Michael J. V. White, et al. Trypsin Potentiates Human Fibrocyte Differentiation. PLoS One. 2013; 8 (8) : e70795. |[5]R Costa, et al. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol. 2008 Jul;154 (5) :1094-103. |[6]F Schmidlin, et al. Protease-activated receptors: how proteases signal to cells. Curr Opin Pharmacol. 2001 Dec;1 (6) :575-82. |[7]Bhupendra S.Kaphalia, et al. Chapter 16 - Biomarkers of acute and chronic pancreatitis. Biomarkers in Toxicology. 2014, Pages 279-289.

Shipping Conditions

Isolate blue ice and the product with bubble pack to avoid direct contact

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PAR2; PAR4

Available Sizes

Curated Selection

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