DB-3-291
DB-3-291 is potent and selective PROTAC CSK degrader, with a Kd of 1 nM (Pink: CSK ligand ; Blue: E3 ligase ligand (HY-103597) ; Black: linker (HY-N2407) ).
Product Specifications
CAS Number
2769753-64-0
UNSPSC
12352005
Target
PROTACs; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db-3-291.html
Purity
99.08
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3OCC(NCCCCNC(CN4CCN(C5=CC(NC6=NC=C(C(NC7=C(Cl)C=CC=C7C)=O)S6)=NC(C)=N5)CC4)=O)=O)=O
Molecular Formula
C41H44ClN11O8S
Molecular Weight
886.37
References & Citations
[1]Donovan KA, et, al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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