Euphohelioscopin A
Product Specifications
CAS Number
87064-61-7
Target
P-gp
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Bioactivity
Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity on the release of cytokine TNF-? (IC50 = 23.7 ± 1.7 uM), IL-6 (IC50 = 46.1 ± 1.1 uM) and chemokine MCP-1 (IC50 = 33.7 ± 3.8 uM) in lipopolysaccharide (LPS) induced RAW 264.7 macrophages without notable cytotoxicity (IC50 > 80 uM) .
Smiles
[H][C@]12C[C@@H](OC(=O)\C=C\C=C/CCC)\C(C)=C/[C@@]3([H])[C@@H](O)[C@H](C)C[C@]3(OC(C)=O)C(=O)\C(C)=C/[C@@]1([H])C2(C)C|c:15,33|
Molecular Formula
C30H42O6
Molecular Weight
498.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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