Wallichinine
Product Specifications
CAS Number
125292-97-9
Target
P-gp
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Bioactivity
Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF) . Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR) .
Smiles
COC1=CC(=O)C(CC=C)=CC1(OC)C(C)=Cc1ccc(OC)c(OC)c1 |w:16.17,c:9,t:2|
Molecular Formula
C22H26O5
Molecular Weight
370.445
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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