Chlorahololide D
Product Specifications
CAS Number
943136-39-8
Target
Bcl-2 Family|||Potassium Channel|||FAK
Related Pathways
Apoptosis|||Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Membrane transporter/Ion channel
Purity
0.9843
Bioactivity
Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential.
Smiles
C(\C(OC)=O)(/C)=C\1/[C@@]2([C@@]34[C@]([C@@]5(C)[C@]6([C@](C6)([C@](COC(/C(=C/C)/C)=O)(O)[C@@]5(CC3=C(COC(C)=O)C(=O)O4)[H])[H])[H])(CC7=C2[C@](C)([C@]8([C@@]7(C8)[H])[H])[C@@H](O)C1=O)[H])[H]
Molecular Formula
C38H44O11
Molecular Weight
676.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/E36A28C8-1B0B-4F5D-B3EA-981CB984788D/TN5335
Available Sizes
Curated Selection
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