Chlorahololide D

Product Specifications

CAS Number

943136-39-8

Target

Bcl-2 Family|||Potassium Channel|||FAK

Related Pathways

Apoptosis|||Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Membrane transporter/Ion channel

Purity

0.9843

Bioactivity

Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential.

Smiles

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